The A19G Polymorphism in the 5′ Untranslated Region of the Human Obese Gene Does Not Affect Leptin Levels in Severely Obese Patients
Recently, the presence of different polymorphisms in the regulatory region of the ob gene has been associated with variations in leptin levels. However, the results of these studies are still contradictory. The aim of the present investigation was to evaluate the presence of the A19G polymorphism in...
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Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2000-10, Vol.85 (10), p.3589-3591 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Recently, the presence of different polymorphisms in the
regulatory region of the ob gene has been associated
with variations in leptin levels. However, the results of these studies
are still contradictory. The aim of the present investigation was to
evaluate the presence of the A19G polymorphism in an Italian population
of obese patients and to verify its association with leptin levels and
anthropometric, metabolic, and clinical parameters. Two hundred five
obese patients [body mass index (BMI) > 36 kg/m2;
135 women and 70 men; mean age, 46.9 ± 14.23 yr] were screened
for presence of the polymorphism; 61 normal-weight controls (mean BMI,
21.05 kg/m2; 53 women, 8 men) were also screened to compare
polymorphism frequency. For obese patients, BMI, waist-to-hip ratio,
resting energy expenditure, body composition, fasting leptin,
total cholesterol, high-density lipoproteins, triglycerides, and
caloric intake were determined. Genotype frequencies in obese and
control subjects were compared using the contingency table chi-square
test; in obese subjects an ANOVA was performed to evaluate association
between the polymorphism and several clinical parameters. No
significant differences in genotype distribution between control and
obese subjects were found. No significant correlations were found
between this polymorphism and serum leptin levels and the other
parameters considered. These findings confirm the results obtained in
both a Finnish and a French population; taken together, these
observations might rule out a significant role for the A19->G
polymorphism in the regulation of leptin levels and other clinical,
anthropometric, and metabolic parameters. |
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ISSN: | 0021-972X 1945-7197 |
DOI: | 10.1210/jcem.85.10.6860 |