New RAS-mutant pancreatic adenocarcinoma with combined BRAF and MEK inhibition for metastatic melanoma

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Veröffentlicht in:	Journal of clinical oncology 2015-04, Vol.33 (11), p.e52-e56
Hauptverfasser:	Carlino, Matteo S, Kwan, Vu, Miller, David K, Saunders, Catherine A B, Yip, Desmond, Nagrial, Adnan M, Tomlinson, Jeanne, Grimmond, Sean M, Scolyer, Richard A, Kefford, Richard F, Biankin, Andrew V, Long, Georgina V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - chemically induced Adenocarcinoma - drug therapy Adenocarcinoma - enzymology Adenocarcinoma - genetics Antineoplastic Combined Chemotherapy Protocols - adverse effects Biopsy DNA Mutational Analysis Humans Imidazoles - administration & dosage Imidazoles - adverse effects Immunohistochemistry Male MAP Kinase Kinase Kinases - antagonists & inhibitors MAP Kinase Kinase Kinases - metabolism Melanoma - drug therapy Melanoma - enzymology Melanoma - genetics Melanoma - secondary Middle Aged Molecular Targeted Therapy Mutation Oximes - administration & dosage Oximes - adverse effects Pancreatic Neoplasms - chemically induced Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - genetics Positron-Emission Tomography Predictive Value of Tests Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Proto-Oncogene Proteins p21(ras) Pyridones - administration & dosage Pyridones - adverse effects Pyrimidinones - administration & dosage Pyrimidinones - adverse effects ras Proteins - genetics Risk Factors Skin Neoplasms - drug therapy Skin Neoplasms - enzymology Skin Neoplasms - genetics Skin Neoplasms - pathology Time Factors Tomography, X-Ray Computed Treatment Outcome
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ISSN:	0732-183X 1527-7755
DOI:	10.1200/JCO.2013.51.5783