Effect of Harmane on Mononeuropathic Pain in Rats

: This study was designed to investigate the effect of the endogenous b‐carboline, harmane, on neuropathic pain produced by chronic constriction injury (CCI) of the sciatic nerve. Thermal allodynia evaluations were made preoperatively, postoperatively on the fifteenth day, and after harmane administ...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2003-12, Vol.1009 (1), p.180-184
Hauptverfasser:	ARICIOGLU, FEYZA, KORCEGEZ, EYLEM, OZYALCIN, SULEYMAN
Format:	Artikel
Sprache:	eng
Schlagworte:	allodynia Animals Carbolines - metabolism Carbolines - therapeutic use chronic constriction injury Cold Temperature Dose-Response Relationship, Drug harmane Harmine - analogs & derivatives Harmine - metabolism Harmine - therapeutic use imidazoline Pain - drug therapy Pain Measurement Rats Rats, Wistar Sciatic Nerve - pathology
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Beschreibung
Zusammenfassung:	: This study was designed to investigate the effect of the endogenous b‐carboline, harmane, on neuropathic pain produced by chronic constriction injury (CCI) of the sciatic nerve. Thermal allodynia evaluations were made preoperatively, postoperatively on the fifteenth day, and after harmane administration. Harmane (1, 2.5, 5, 10, or 20 mg/kg) was administered intraperitoneally for 5 days beginning from postoperative day 15. Treatment with harmane had a profound anti‐allodynic effect in a dose‐dependent manner. In conclusion, harmane might provide a new approach to treatment of neuropathic pain.
ISSN:	0077-8923 1749-6632
DOI:	10.1196/annals.1304.021