Long-Term Monitoring of Tricyclic Antidepressant Plasma Concentrations

Long-Term Monitoring of Tricyclic Antidepressant Plasma Concentrations

Plasma levels of antidepressant drugs were measured in 17 depressed patients at roughly monthly intervals over follow-up periods of three to 26 months. Good results in seven were associated with small fluctuations in level from visit to visit, while big fluctuations were associated with poor outcome...

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Veröffentlicht in:British journal of psychiatry 1980-11, Vol.137 (5), p.444-451
Hauptverfasser: Loo, Agrégé Henry, Benyacoub, Kader, Rovei, Vincenzo, Altamura, Carlo A., Vadrot, Marthe, Morselli, Paolo L.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antidepressive Agents, Tricyclic - adverse effects
Antidepressive Agents, Tricyclic - blood
Antidepressive Agents, Tricyclic - therapeutic use
Female
Humans
Male
Middle Aged
Patient Compliance
Time Factors
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Beschreibung
Zusammenfassung:Plasma levels of antidepressant drugs were measured in 17 depressed patients at roughly monthly intervals over follow-up periods of three to 26 months. Good results in seven were associated with small fluctuations in level from visit to visit, while big fluctuations were associated with poor outcome. Such fluctuations were probably from poor compliance or drug interaction from self-medication. Severe side effects and cardiotoxicity were associated with high levels.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.137.5.444