Inflammatory Marker Levels, Age, Race and Prior Treatment Burden Independently Predict Delayed Hematologic Recovery after BCMA-Directed CART Therapy in Multiple Myeloma

Inflammatory Marker Levels, Age, Race and Prior Treatment Burden Independently Predict Delayed Hematologic Recovery After BCMA-directed CART Therapy in Multiple Myeloma Introduction: With the advent of two approved anti-BCMA products and several additional investigational cellular therapies, the use of BCMA-directed chimeric antigen receptor T-cell therapy (CART) is expanding for the treatment of multiple myeloma (MM). Prolonged cytopenias have been observed in a subset of CART recipients across products. The etiology and natural history of these cytopenias has not been thoroughly evaluated in the literature. We present a comprehensive multivariable model of hematologic recovery post-CART in an analysis of 140 MM CART recipients from a large academic center. Methods: We retrospectively reviewed electronic health record data for relapsed/refractory MM patients from our institution who received a BCMA-directed CART product between 2017 & 2022. For each patient, all available lab values of hemoglobin (Hgb), platelet count (Plt) and absolute neutrophil count (ANC) were recorded and graded according to CTCAE v5.0 criteria. Missing lab values were linearly interpolated between available measurements. We defined time to recovery for each blood count as the number of days from CART infusion (day 0) until the first day of a 30-day-long period without any grade 3 or 4 (G3/4) values. Time to recovery from any G3/4 myeloid cytopenia (i.e., anemia, thrombocytopenia, and neutropenia) was also calculated. Next, we classified patients according to the CAR-HEMATOTOX scoring system (Rejeski et al, ASH 2022), a tool which incorporates baseline blood counts and inflammatory parameters such as C-reactive protein and ferritin prior to lymphodepletion to predict the risk of post-CART hematotoxicity. Kaplan-Meier curves were generated treating recovery from G3/4 cytopenia as the ‘event’ and censoring patients at the time of PD. A Cox proportional hazards model was used for multivariate analysis. Results: A total of 140 MM patients who received a BCMA-directed CART product at ISMMS were included in the study. 107 patients (76%) received CART as part of a clinical trial and 33 (24%) commercially. Median age at CART infusion was 62 (range 35-83) and median number of prior lines of therapy was 5 (range 1-18). 102/140 patients (73%) were previously treated with high-dose melphalan and autologous stem cell transplantation, of which 23 had more than one prior transplant. Median CAR-HEMA