Deciphering the Immune Microenvironment in Waldenstrom's Macroglobulinemia

Deciphering the Immune Microenvironment in Waldenstrom's Macroglobulinemia

Recent studies have demonstrated the occurrence of somatic mutations of MYD88 and CXCR4 as key players in Waldenstrom's Macroglobulinemia (WM) pathogenesis and disease progression. Despite the significant improvement in the knowledge of the molecular mechanisms supporting WM biology whether imm...

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Veröffentlicht in:Blood 2023-11, Vol.142 (Supplement 1), p.4690-4690
Hauptverfasser: Sacco, Antonio, Desantis, Vanessa, Celay, Jon, Giustini, Viviana, Rigali, Fabio, Savino, Francesco, Cea, Michele, Soncini, Debora, Cagnetta, Antonia, Solimando, Antonio Giovanni, D'Aliberti, Deborah, Spinelli, Silvia, Ramazzotti, Daniele, Almici, Camillo, Todoerti, Katia, Neri, Antonino, Anastasia, Antonella, Tucci, Alessandra, Motta, Marina, Chiarini, Marco, Kawano, Yawara, Martinez-Climent, Jose A, Piazza, Rocco, Roccaro, Aldo
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Sprache:eng
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Zusammenfassung:Recent studies have demonstrated the occurrence of somatic mutations of MYD88 and CXCR4 as key players in Waldenstrom's Macroglobulinemia (WM) pathogenesis and disease progression. Despite the significant improvement in the knowledge of the molecular mechanisms supporting WM biology whether immunosuppressive mechanisms could contribute to WM pathogenesis remains unexplored. We interrogated the transcriptome signatures of the bone marrow (BM) microenvironment of WM patients (n:22) as compared to healthy individuals (n:10), we found a significant enrichment for a Treg-signature, and for CD40/CD40L signaling-related genes (FDR
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2023-188408