Systematic Literature Review of Incidence and Management of Non-HCT-Related Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (VOD/SOS)

Background: VOD/SOS is a potentially life-threatening complication caused by damage to sinusoidal endothelial cells. It has historically been associated with toxicity from conditioning regimens preceding hematopoietic cell transplantation (HCT), but its epidemiology and characteristics outside the HCT setting are not well understood. We conducted a systematic review to examine the incidence, mortality, diagnosis, and the burden of illness of non-HCT VOD/SOS. Methods: We searchedMEDLINE and Embase (2002-2023), as well as recent congress proceedings (2019-2023) for studies reporting the following in the non-HCT VOD/SOS setting: incidence, diagnosis, relevant medical history, disease management, clinical burden, health-related quality of life, costs, and patients' (pts) unmet needs. All study designs were eligible except case series with