Prevalence and Overall Survival of Low Count Monoclonal B-Cell Lymphocytosis (LC-MBL): A Screening Study of 8,297 Individuals from the Mayo Clinic Biobank

Prevalence and Overall Survival of Low Count Monoclonal B-Cell Lymphocytosis (LC-MBL): A Screening Study of 8,297 Individuals from the Mayo Clinic Biobank

Monoclonal B-cell lymphocytosis (MBL) is one of the most common pre-malignant conditions and is characterized by a circulating population of clonal B-cells with an absolute clonal B-cell count < 5x10 9/L and no evidence of lymphadenopathy, organomegaly, or cytopenias. MBL can be classified by the...

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Veröffentlicht in:Blood 2021-11, Vol.138 (Supplement 1), p.2632-2632
Hauptverfasser: Slager, Susan L., Parikh, Sameer A., Achenbach, Sara J., Kleinstern, Geffen, Boddicker, Nicholas J., Norman, Aaron D., Rabe, Kari G., Lesnick, Connie E., Call, Timothy G., Olson, Janet E., Cerhan, James R., Kay, Neil E., Vachon, Celine M., Braggio, Esteban, Hanson, Curtis A., Shanafelt, Tait
Format: Artikel
Sprache:eng
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Zusammenfassung:Monoclonal B-cell lymphocytosis (MBL) is one of the most common pre-malignant conditions and is characterized by a circulating population of clonal B-cells with an absolute clonal B-cell count < 5x10 9/L and no evidence of lymphadenopathy, organomegaly, or cytopenias. MBL can be classified by the immunophenotype: CLL-like MBL (CD5+, CD20dim), atypical MBL (CD5+, CD20+), or non-CLL-like MBL (CD5-, CD20+), as well as by the size of the clone (low-count or high-count) with low-count MBL (LC-MBL) defined as clonal B-cell
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2021-153320