Epigenetically Enhanced MED12L in ETO2-GLIS2 Positive Pediatric Acute Megakaryoblastic Leukemia Is Associated with Resistance to the CDK8 Inhibitors

Epigenetically Enhanced MED12L in ETO2-GLIS2 Positive Pediatric Acute Megakaryoblastic Leukemia Is Associated with Resistance to the CDK8 Inhibitors

Introduction. ETO2-GLIS2 (aka CBFA2T3-GLIS2) is the most common (30%) alteration in pediatric de novo acute megakaryoblastic leukemia (AMKL). These patients have poor response to induction therapy, a high incidence of relapse (~90%), and dismal 5-year survival rates (

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Veröffentlicht in:Blood 2021-11, Vol.138 (Supplement 1), p.2208-2208
Hauptverfasser: Roy Choudhury, Samrat, Bird, Jordan T, Byrum, Stephanie, Jester, Dane, Davidson, Troy, Almeida Gonzalez, Giselle, Becton, David, Smith, Jenny L., Ries, Rhonda E., Meshinchi, Soheil, Farrar, Jason E
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Sprache:eng
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Zusammenfassung:Introduction. ETO2-GLIS2 (aka CBFA2T3-GLIS2) is the most common (30%) alteration in pediatric de novo acute megakaryoblastic leukemia (AMKL). These patients have poor response to induction therapy, a high incidence of relapse (~90%), and dismal 5-year survival rates (
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2021-148574