Torque teno mini virus as a cause of childhood acute promyelocytic leukemia lacking PML/RARA fusion

Astolf et al provide the first report of acute promyelocytic leukemia driven by viral insertion into the RARA locus. This represents a clear demonstration of a pathology driven by the member of the anelloviruses, a group of viruses otherwise thought to have minimal or no pathogenic potential.

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Bibliographische Detailangaben
Veröffentlicht in:	Blood 2021-11, Vol.138 (18), p.1773-1777
Hauptverfasser:	Astolfi, Annalisa, Masetti, Riccardo, Indio, Valentina, Bertuccio, Salvatore Nicola, Messelodi, Daria, Rampelli, Simone, Leardini, Davide, Carella, Matteo, Serravalle, Salvatore, Libri, Virginia, Bandini, Jessica, Volinia, Stefano, Candela, Marco, Pession, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Anelloviridae - pathogenicity Anelloviridae - physiology Antineoplastic Agents - therapeutic use Child Female Humans Karyotype Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - pathology Leukemia, Promyelocytic, Acute - therapy Oncogene Proteins, Fusion - genetics Oncogenic Viruses - pathogenicity Oncogenic Viruses - physiology Retinoic Acid Receptor alpha Torque teno virus - pathogenicity Torque teno virus - physiology Tretinoin - therapeutic use
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Beschreibung
Zusammenfassung:	Astolf et al provide the first report of acute promyelocytic leukemia driven by viral insertion into the RARA locus. This represents a clear demonstration of a pathology driven by the member of the anelloviruses, a group of viruses otherwise thought to have minimal or no pathogenic potential.
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood.2021011677