VAV1-GFP Fusion Protein Generated By Intron-Based Genome Editing through CRISPR/Cas9 Leads to Spontaneous Activation in TCR Signaling

Recurrent VAV1 mutations and gene fusions (VAV1-THAP4, VAV1-MYO1F, and VAV1-S100A7) have been identified in peripheral T-cell lymphoma (PTCL) including angioimmunoblastic T-cell lymphoma (AITL) patients. A common theme of these genetic aberrations is the loss of the auto-inhibitory C-terminal SH3 do...

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Veröffentlicht in:	Blood 2020-11, Vol.136 (Supplement 1), p.27-28
Hauptverfasser:	Liu, Xiaoqian, Li, Yuping, Liu, Xuxiang, Qi, Wei, Zhang, Jibin, Shetty, Kunal, Iqbal, Javeed, Chan, Wing C.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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