p53 Mediated Bone Marrow Mesenchymal Stem Cell Expansion Supports Acute Myeloid Leukemia Development

p53 Mediated Bone Marrow Mesenchymal Stem Cell Expansion Supports Acute Myeloid Leukemia Development

Acute myeloid leukemia (AML) is a heterogeneous disease that develops within a complex microenvironment. Reciprocal interactions between the bone marrow mesenchymal stem/stromal cells (BM-MSCs) and AML cells can promote AML progression and resistance to chemotherapy (Jacamo et al., 2014). We have re...

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Veröffentlicht in:Blood 2019-11, Vol.134 (Supplement_1), p.523-523
Hauptverfasser: Pourebrahimabadi, Rasoul, Alaniz, Zoe, Ostermann, Lauren B, Luong, Hung Alex, Montoya, Rafael Heinz, Ruvolo, Peter P., Kornblau, Steven M., Khoury, Joseph D., Bueso-Ramos, Carlos E., Andreeff, Michael
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Sprache:eng
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Zusammenfassung:Acute myeloid leukemia (AML) is a heterogeneous disease that develops within a complex microenvironment. Reciprocal interactions between the bone marrow mesenchymal stem/stromal cells (BM-MSCs) and AML cells can promote AML progression and resistance to chemotherapy (Jacamo et al., 2014). We have recently reported that BM-MSCs derived from AML patients (n=103) highly express p53 and p21 compared to their normal counterparts (n=73 p
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2019-127245