Genomic Landscape of Young ATLL Patients Identifies Frequent Targetable CD28 Fusions

Genomic Landscape of Young ATLL Patients Identifies Frequent Targetable CD28 Fusions

Introduction Adult T-cell leukemia/lymphoma (ATLL) is a T-cell neoplasm induced by human T-cell leukemia virus type 1 (HTLV-1). In endemic areas, HTLV-1 infection typically occurs during breastfeeding but the median age of ATLL presentation in Japan is >70. Approximately 5% of ATLL patients in Ja...

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Veröffentlicht in:Blood 2019-11, Vol.134 (Supplement_1), p.2760-2760
Hauptverfasser: Yoshida, Noriaki, Shigemori, Kay, Ng, Samuel Y., Nirmal, Ajit, Donaldson, Nicolas, Cordero, Nicolas, Stevenson, Kristen E., Bu, Xia, Takeuchi, Mai, Ohshima, Koichi, Yoda, Akinori, Weinstock, David M
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Sprache:eng
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Zusammenfassung:Introduction Adult T-cell leukemia/lymphoma (ATLL) is a T-cell neoplasm induced by human T-cell leukemia virus type 1 (HTLV-1). In endemic areas, HTLV-1 infection typically occurs during breastfeeding but the median age of ATLL presentation in Japan is >70. Approximately 5% of ATLL patients in Japan present at age
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2019-122525