NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

NRAS G12V maintains leukemia self-renewal in a genetically engineered murine model of AML. NRAS G12V differentially regulates transcription and signaling among leukemic subpopulations.

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Veröffentlicht in:Blood 2014-11, Vol.124 (22), p.3274-3283
Hauptverfasser: Sachs, Zohar, LaRue, Rebecca S., Nguyen, Hanh T., Sachs, Karen, Noble, Klara E., Mohd Hassan, Nurul Azyan, Diaz-Flores, Ernesto, Rathe, Susan K., Sarver, Aaron L., Bendall, Sean C., Ha, Ngoc A., Diers, Miechaleen D., Nolan, Garry P., Shannon, Kevin M., Largaespada, David A.
Format: Artikel
Sprache:eng
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Zusammenfassung:NRAS G12V maintains leukemia self-renewal in a genetically engineered murine model of AML. NRAS G12V differentially regulates transcription and signaling among leukemic subpopulations.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2013-08-521708