Clotting and cancer progression: platelets count

Clotting and cancer progression: platelets count

In knockout mice models of metastasis, platelets, activation of platelet protease-activated receptor 4 (PAR4), and fibrinogen/fibrin formation play key roles in the blood-borne metastasis of tumor cells with procoagulant activity, whereas activation of endothelial cell PAR1 and PAR2 does not appear...

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Veröffentlicht in:Blood 2004-07, Vol.104 (2), p.300-300
1. Verfasser: Bromberg, Michael E.
Format: Artikel
Sprache:eng
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Zusammenfassung:In knockout mice models of metastasis, platelets, activation of platelet protease-activated receptor 4 (PAR4), and fibrinogen/fibrin formation play key roles in the blood-borne metastasis of tumor cells with procoagulant activity, whereas activation of endothelial cell PAR1 and PAR2 does not appear to have a critical function in this process.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2004-05-1815