Simultaneous detection of MDR1 and WT1 gene expression to predict the prognosis of adult acute lymphoblastic leukemia

The interaction between Wilms tumor gene 1 (WT1) and the promoter region of the multidrug resistance-1 (MDR1) gene has been previously reported but the clinical significance of the coexpression of WT1 and MDR1 in acute lymphoblastic leukemia (ALL) is still largely unknown. In this study, the express...

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Veröffentlicht in:	Hematology (Luxembourg) 2010-04, Vol.15 (2), p.74-80
Hauptverfasser:	Xu, Bing, Song, Xiaoyan, Yip, Nga Chi, Xiao, Pingnan, Zhang, Yanyan, Wang, Weiguang, Zhou, Shuyun
Format:	Artikel
Sprache:	eng
Schlagworte:	ACUTE LYMPHOBLASTIC LEUKEMIA Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - analysis ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Biomarkers, Tumor - analysis Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Bone Marrow - chemistry Bone Marrow - metabolism Bone Marrow - pathology Cohort Studies Cyclophosphamide - administration & dosage Cytarabine - administration & dosage Dexamethasone - administration & dosage Disease-Free Survival Doxorubicin - administration & dosage Drug Resistance, Neoplasm - genetics Female Gene Expression Regulation, Leukemic Genes, Wilms Tumor Humans Male MDR1 Methotrexate - administration & dosage Middle Aged MULTIPLEX FLUORESCENCE REAL-TIME QUANTITATIVE POLYMERASE CHAIN REACTION Neoplasm Proteins - analysis Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology PROGNOSIS Remission Induction RNA, Messenger - biosynthesis RNA, Neoplasm - biosynthesis Vincristine - administration & dosage WT1 Proteins - analysis WT1 Proteins - biosynthesis WTL Young Adult
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Zusammenfassung:	The interaction between Wilms tumor gene 1 (WT1) and the promoter region of the multidrug resistance-1 (MDR1) gene has been previously reported but the clinical significance of the coexpression of WT1 and MDR1 in acute lymphoblastic leukemia (ALL) is still largely unknown. In this study, the expression levels of WT1 and MDR1 mRNA in 57 adult ALL patients were simultaneously detected using multiplex fluorescence real-time quantitative polymerase chain reaction. The expression levels of WT1 and MDR1 in bone marrow samples of adult ALL patients were significantly higher than those in the normal samples (P
ISSN:	1607-8454 1607-8454
DOI:	10.1179/102453310X12583347009937