Two New Steroidal Saponins from Solanum procumbens

Two new steroidal saponins, solaprocumosides A (1) and B (2), and a known compound paniculonin B (3) were isolated from the aerial parts of Solanum procumbens. Their chemical structures were determined by analysis of HR-ESI-MS and NMR spectra. Compound 1 had ketone functional groups at C-16 and C-22 of sterol skeleton which is rarely found in nature. Meanwhile, compound 2 could be form by oxidative breakdown C-20/C-22 bonding of a furostane-type saponin. Compounds 1–3 showed weak cytotoxicity against HepG2 cell line with IC50 values of 55.7 ± 1.5, 48.1 ± 2.2, and 78.3 ± 2.4 μM, respectively.