Potent α-Glucosidase Inhibitors from the Roots of Aruncus sylvester
Two new acyl glucoses, 1,3,6-tri-O-(E)-caffeoyl-β-D-glucopyranoside (1) and 3,4-di-O-(E)-caffeoyl-α/β-D-glucopyranose (2), along with four known ones (3–6), were isolated from the roots of Aruncus sylvester. Their structures were elucidated on the basis of NMR spectroscopic analysis. Compounds 1 and...
Gespeichert in:
Veröffentlicht in: | Natural product communications 2018-08, Vol.13 (8) |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Two new acyl glucoses, 1,3,6-tri-O-(E)-caffeoyl-β-D-glucopyranoside (1) and 3,4-di-O-(E)-caffeoyl-α/β-D-glucopyranose (2), along with four known ones (3–6), were isolated from the roots of Aruncus sylvester. Their structures were elucidated on the basis of NMR spectroscopic analysis. Compounds 1 and 3 showed potent α-glucosidase inhibitory activity with IC50 values of 1.16 μM and 0.71 μM, respectively. |
---|---|
ISSN: | 1934-578X 1555-9475 |
DOI: | 10.1177/1934578X1801300817 |