Isoflavonoids from Desmodium heterophyllum Aerial Parts

Five isoflavanoids including one new, (3R)–2′,4′,5,7-tetrahydroxy-6-methylisoflavanone (1), were isolated from the aerial parts of Desmodium heterophyllum. Their structures were elucidated using spectroscopic methods. Their inhibitory effects on digestive enzymes α-glucosidase and α-amylase were eva...

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Veröffentlicht in:Natural product communications 2018-06, Vol.13 (6)
Hauptverfasser: Ha, Le Minh, Luyen, Nguyen Thi, Phuong, Ngo Thi, Huyen, Do Thi Thanh, Huong, Le Mai, Quan, Pham Minh, Hiep, Nguyen Tuan, Dat, Nguyen Tien
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Sprache:eng
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Zusammenfassung:Five isoflavanoids including one new, (3R)–2′,4′,5,7-tetrahydroxy-6-methylisoflavanone (1), were isolated from the aerial parts of Desmodium heterophyllum. Their structures were elucidated using spectroscopic methods. Their inhibitory effects on digestive enzymes α-glucosidase and α-amylase were evaluated. Genistein (5) and dalbergioidin (2) inhibited both enzymes. Their IC50 values were found at 110.4 and 162.8 μM for α-amylase, and at 257.3 and 412.6 μM for α-glucosidase, respectively.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1801300612