Isoflavonoids from Desmodium heterophyllum Aerial Parts
Five isoflavanoids including one new, (3R)–2′,4′,5,7-tetrahydroxy-6-methylisoflavanone (1), were isolated from the aerial parts of Desmodium heterophyllum. Their structures were elucidated using spectroscopic methods. Their inhibitory effects on digestive enzymes α-glucosidase and α-amylase were eva...
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Veröffentlicht in: | Natural product communications 2018-06, Vol.13 (6) |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Five isoflavanoids including one new, (3R)–2′,4′,5,7-tetrahydroxy-6-methylisoflavanone (1), were isolated from the aerial parts of Desmodium heterophyllum. Their structures were elucidated using spectroscopic methods. Their inhibitory effects on digestive enzymes α-glucosidase and α-amylase were evaluated. Genistein (5) and dalbergioidin (2) inhibited both enzymes. Their IC50 values were found at 110.4 and 162.8 μM for α-amylase, and at 257.3 and 412.6 μM for α-glucosidase, respectively. |
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ISSN: | 1934-578X 1555-9475 |
DOI: | 10.1177/1934578X1801300612 |