Asymmetric Synthesis of Tetrahydroisoquinoline Alkaloids Using Ellman's Chiral Auxiliary

Chiral t-butylsulfinamide has been successfully employed for the stereoselective synthesis of 1-benzyl tetrahydroisoquinoline alkaloids. This is the first report on the synthesis of chiral 1-benzyltetrahydroisoquinoline natural products using tert-butylsulfinamide through a haloamide cyclization.

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Bibliographische Detailangaben
Veröffentlicht in:	Natural product communications 2017-10, Vol.12 (10)
Hauptverfasser:	Reddy, Y. Vikram, Biradar, Dhanraj O., Reddy, B. Jagan Mohan, Rathod, Aravinda, Himabindu, M., Reddya, B. V. Subba
Format:	Artikel
Sprache:	eng
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Beschreibung
Zusammenfassung:	Chiral t-butylsulfinamide has been successfully employed for the stereoselective synthesis of 1-benzyl tetrahydroisoquinoline alkaloids. This is the first report on the synthesis of chiral 1-benzyltetrahydroisoquinoline natural products using tert-butylsulfinamide through a haloamide cyclization.
ISSN:	1934-578X 1555-9475
DOI:	10.1177/1934578X1701201019