Saikosaponins from Bupleurum chinense and Inhibition of HBV DNA Replication Activity

Saikosaponins from Bupleurum chinense and Inhibition of HBV DNA Replication Activity

One new saikosaponin, 3β,16α,23,28,30-pentahydroxyoleana-11,13(18)-diene 3-O-β-D-fucopyranoside (1), along with eight known compounds, saikosaponin a, b1, b2, b3, d, g, k, and l were isolated from the MeOH extract of the aerial parts of Bupleurum chinense DC. Their structures were elucidated by 1D a...

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Veröffentlicht in:Natural product communications 2008-02, Vol.3 (2)
Hauptverfasser: Yin, Feng, Pan, Ruixiang, Chen, Rongmin, Hu, Lihong
Format: Artikel
Sprache:eng
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Zusammenfassung:One new saikosaponin, 3β,16α,23,28,30-pentahydroxyoleana-11,13(18)-diene 3-O-β-D-fucopyranoside (1), along with eight known compounds, saikosaponin a, b1, b2, b3, d, g, k, and l were isolated from the MeOH extract of the aerial parts of Bupleurum chinense DC. Their structures were elucidated by 1D and 2D NMR spectral interpretation, as well as by chemical degradation. Saikosaponin d exhibited significant bioactivity in inhibiting HBV DNA replication.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X0800300209