Primary leiomyosarcoma of the uterine cervix: report of 4 cases, systematic review, and meta-analysis

Background: Primary cervical leiomyosarcomas (CLMS) constitute 21% of all cervical sarcomas. Because of their rarity, to our knowledge, fewer than 40 cases have been reported. The aim of this study is to evaluate the clinical and surgical–pathological features, prognosis, treatment options, and surv...

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Veröffentlicht in:	Tumori 2020-10, Vol.106 (5), p.413-423
Hauptverfasser:	Kiliç, Cigdem, Yuksel, Dilek, Cakir, Caner, Turkmen, Osman, Kimyon Comert, Gunsu, Başaran, Derman, Turan, Taner
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cervix Uteri - pathology Chemotherapy, Adjuvant - methods Female Humans Hysterectomy Leiomyosarcoma - diagnosis Leiomyosarcoma - drug therapy Leiomyosarcoma - pathology Leiomyosarcoma - radiotherapy Middle Aged Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - radiotherapy Prognosis Radiotherapy, Adjuvant - adverse effects Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy
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Zusammenfassung:	Background: Primary cervical leiomyosarcomas (CLMS) constitute 21% of all cervical sarcomas. Because of their rarity, to our knowledge, fewer than 40 cases have been reported. The aim of this study is to evaluate the clinical and surgical–pathological features, prognosis, treatment options, and survival of primary CLMS. Methods: A systematic review of the medical literature was conducted to evaluate articles about primary CLMS. The literature was searched between 1959 and May 2019. On final evaluation, there were 29 articles (one consisted of 8 cases; one consisted of 3 cases) and 42 cases with the addition of our 4 cases. Results: Age (⩾48 versus ⩽47 years) (hazard ratio.HR], 4.528; 95% confidence interval.CI], 1.550–13.227; p=0.006) and mitoses count (
ISSN:	0300-8916 2038-2529
DOI:	10.1177/0300891620919161