Systematic Review of HPV-Related Head and Neck Cancers in Latin American Countries

Objectives: Human papillomavirus (HPV)–related head and neck squamous cell carcinoma (HNSCC) is extensively studied in the developed world but relatively less studied in developing countries. The goal of this review is to determine the state of knowledge of HPV-related HNSCC in Latin American countries (LACs) and to highlight areas that would benefit from additional research. Methods: Databases searched included PubMed and Virtual health library (LILAC). All Latin American studies addressing HPV-related HNSCC of oral cavity, oropharynx, and larynx were selected. We did not restrict studies by type of study, sample size, or method of HPV detection; however, case reports were excluded. Each article was reviewed for incidence/prevalence of HPV-positive HNSCC, demographics, social history, and clinical outcomes. Results: Thirty-eight full-text articles were reviewed that identified HPV-positivity in 33%, HPV 16 being most prevalent. Twenty-three of 38 (60%) had a sample size