Incidence and Survival Trends of Sinonasal Adenocarcinoma from 1973 to 2009

Objectives: Study the incidence and survival of patients with sinonasal adenocarcinoma (SNA) between 1973 and 2009 using the Surveillance, Epidemiology, and End Result (SEER) database. Methods: A retrospective cohort study using the United States National Cancer Institute’s SEER registry was analyzed to study the incidence and survival for SNA from 1973-2009. Analysis was conducted based on race and gender. Results: In total, 885 cases of SNA were reported. Males accounted for 50.17%, while females accounted for 49.83%, amounting to a 1.01:1.00 male to female ratio. Analysis of incidence trends revealed a statistically significant decline in incidence of overall population, females, blacks, and “others” (P < 0.05). Overall 20-year survival for SNA over the past 30 years was 30.25%. Survival data were additionally analyzed by gender revealing females to have a slightly better survival than males (P > 0.05). When survival was stratified by race, “others” had the best survival, followed by whites and blacks, respectively, although this was not statistically significant. Conclusions: The overall incidence of SNA has significantly declined over the past 30 years. The highest decrease in incidence was observed in “others,” when compared to whites and blacks. Moreover, while the female incidence significantly declined, the male incidence rate has stayed stable over the past 30 years. Overall long-term survival has increased over the last 30 years. No significant difference in survival was noted for gender and race.