Spontaneous Ovarian Choriocarcinoma, Yolk Sac Carcinoma, and Teratoma in B6C3F1 Mice: A Case Report

Three ovarian neoplasms (choriocarcinoma, yolk sac carcinoma, and teratoma) were diagnosed in a 2 yr carcinogenicity study involving B6C3F1 mice. The yolk sac carcinoma and the teratoma occurred in opposite ovaries of a single female mouse that was sacrificed in extremis on study day 725. The chorio...

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Veröffentlicht in:	Toxicologic pathology 1993-01, Vol.21 (1), p.91-98
Hauptverfasser:	Frith, Charles H., Evans, Mark G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Biological and medical sciences Choriocarcinoma - pathology Disease Models, Animal Female Medical sciences Mesonephroma - pathology Mice Mice, Inbred Strains Ovarian Cysts - pathology Ovarian Diseases - pathology Ovarian Neoplasms - pathology Spontaneous animal tumors Teratoma - pathology Tumors
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Zusammenfassung:	Three ovarian neoplasms (choriocarcinoma, yolk sac carcinoma, and teratoma) were diagnosed in a 2 yr carcinogenicity study involving B6C3F1 mice. The yolk sac carcinoma and the teratoma occurred in opposite ovaries of a single female mouse that was sacrificed in extremis on study day 725. The choriocarcinoma occurred in a female mouse that was sacrificed in extremis on study day 565. These neoplasms were considered to be spontaneous in origin.
ISSN:	0192-6233 1533-1601
DOI:	10.1177/019262339302100112