Air Pollution, Genetic Factors, and the Risk of Lung Cancer A Prospective Study in the UK Biobank

Rationale: Both genetic and environmental factors contribute to lung cancer, but the degree to which air pollution modifies the impact of genetic susceptibility on lung cancer remains unknown. Objectives: To investigate whether air pollution and genetic factors jointly contribute to incident lung ca...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of respiratory and critical care medicine 2021-10, Vol.204 (7), p.817-825
Hauptverfasser:	Huang, Yanqian, Zhu, Meng, Ji, Mengmeng, Fan, Jingyi, Xie, Junxing, Wei, Xiaoxia, Jiang, Xiangxiang, Xu, Jing, Chen, Liang, Yin, Rong, Wang, Yuzhuo, Dai, Juncheng, Jin, Guangfu, Xu, Lin, Hu, Zhibin, Ma, Hongxia, Shen, Hongbing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Air Pollutants - analysis Air Pollutants - toxicity Air pollution Air Pollution - adverse effects Air Pollution - analysis Air Pollution - statistics & numerical data Biological Specimen Banks Critical Care Medicine Environmental Exposure - adverse effects Environmental Exposure - analysis Environmental Exposure - statistics & numerical data Female Follow-Up Studies Gene-Environment Interaction General & Internal Medicine Genetic Predisposition to Disease Genetics Health risks Humans Life Sciences & Biomedicine Lung cancer Lung Neoplasms - epidemiology Lung Neoplasms - etiology Male Middle Aged Nitrogen Oxides - toxicity Particulate Matter - analysis Particulate Matter - toxicity Polymorphism, Single Nucleotide Proportional Hazards Models Prospective Studies Respiratory System Risk Factors Science & Technology United Kingdom - epidemiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Rationale: Both genetic and environmental factors contribute to lung cancer, but the degree to which air pollution modifies the impact of genetic susceptibility on lung cancer remains unknown. Objectives: To investigate whether air pollution and genetic factors jointly contribute to incident lung cancer. Methods: We analyzed data from 455,974 participants (53% women) without previous cancer at baseline in the UK Biobank. The concentrations of particulate matter (PM) (PM
ISSN:	1073-449X 1535-4970
DOI:	10.1164/rccm.202011-4063OC