A case of gastric limited amyloidosis diagnosed by endoscopic submucosal dissection

The case was 60 year-old female. She visited the clinic for examining a submucosal tumor of the greater curvature of the middle body of the stomach. Blood examinations showed mild anemia, and serum amyloid A was within normal range. Endoscopic ultrasonography showed that the lesion had a uniform hypoechoic interior and localized in the third layer. A small amount of amyloid deposits was found in the biopsy specimen histologically. No significant changes in lesion size were observed one year later, and biopsy showed no amyloid deposits. Endoscopic submucosal dissection (ESD) was performed for diagnosis and treatment. Histopathological examination showed amyloid deposits throughout the resected lesion. In addition, immunostaining was positive for AA amyloid protein, therefore, the diagnosis of the SMT was AA amyloidosis. The patient had no amyloid deposits in other organs and was diagnosed with gastric-limited AA amyloidosis. Here, we reported a rare case of gastric limited amyloidosis diagnosed by ESD.