Angiotensin AT 1 Receptor Stimulates Heat Shock Protein 27 Phosphorylation In Vitro and In Vivo

Angiotensin AT 1 Receptor Stimulates Heat Shock Protein 27 Phosphorylation In Vitro and In Vivo

The angiotensin type 1 receptor (AT 1 ) exerts a variety of its signaling and cellular actions through its effects on protein phosphorylation. Phosphoproteomic analysis of angiotensin (Ang) II–stimulated aortic smooth muscle cells revealed that heat shock protein 27 (HSP27) represents a major protei...

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Veröffentlicht in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2001-12, Vol.38 (6), p.1260-1265
Hauptverfasser: Meier, Matthias, King, George L., Clermont, Allen, Perez, Alexandra, Hayashi, Michio, Feener, Edward P.
Format: Artikel
Sprache:eng
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Zusammenfassung:The angiotensin type 1 receptor (AT 1 ) exerts a variety of its signaling and cellular actions through its effects on protein phosphorylation. Phosphoproteomic analysis of angiotensin (Ang) II–stimulated aortic smooth muscle cells revealed that heat shock protein 27 (HSP27) represents a major protein phosphorylation target of the AT 1 signaling pathway. Stimulation of cells with Ang II resulted in 1.7-fold ( P
ISSN:0194-911X
1524-4563
DOI:10.1161/hy1201.096573