Angiotensin II AT 1A Receptor Antisense Lowers Blood Pressure in Acute 2-Kidney, 1-Clip Hypertension
Abstract — — To test the effectiveness of antisense oligonucleotides targeted to the angiotensin type 1A (AT 1A ) receptor mRNA on blood pressure reduction, the 2-kidney, 1-clip (2K1C) Goldblatt model of hypertension was studied in the acute phase of hypertension, when the peripheral renin-angiotens...
Gespeichert in:
| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2001-09, Vol.38 (3), p.674-678 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | Abstract
—
— To test the effectiveness of antisense oligonucleotides targeted to the angiotensin type 1A (AT
1A
) receptor mRNA on blood pressure reduction, the 2-kidney, 1-clip (2K1C) Goldblatt model of hypertension was studied in the acute phase of hypertension, when the peripheral renin-angiotensin system is overactive. A single injection of AT
1A
receptor antisense oligodeoxynucleotides significantly reduced systolic blood pressure for a period of 8 days in 2K1C rats after clipping, from 157.5±5 mm Hg on day 7 to 141.3±3.0 mm Hg on day 15 after clipping (
P |
|---|---|
| ISSN: | 0194-911X 1524-4563 |
| DOI: | 10.1161/hy09t1.095207 |