Challenges of Decision Making Regarding Futility in a Randomized Trial: The Interventional Management of Stroke III Experience

BACKGROUND AND PURPOSE—Interventional Management of Stroke (IMS) III is a randomized, parallel arm trial comparing the approach of intravenous tissue-type plasminogen activator followed by endovascular treatment with intravenous tissue-type plasminogen activator alone in patients with acute ischemic...

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Veröffentlicht in:	Stroke (1970) 2014-05, Vol.45 (5), p.1408-1414
Hauptverfasser:	Yeatts, Sharon D, Martin, Renee H, Coffey, Christopher S, Lyden, Patrick D, Foster, Lydia D, Woolson, Robert F, Broderick, Joseph P, Di Tullio, Marco R, Jungreis, Charles A, Palesch, Yuko Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Brain Ischemia - drug therapy Brain Ischemia - therapy Combined Modality Therapy - standards Data Interpretation, Statistical Decision Making - physiology Disease Management Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - therapeutic use Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Medical Futility Medical sciences Nervous system (semeiology, syndromes) Neurology Randomized Controlled Trials as Topic - standards Research Design - standards Severity of Illness Index Stroke - drug therapy Stroke - therapy Thrombolytic Therapy - standards Tissue Plasminogen Activator - administration & dosage Tissue Plasminogen Activator - therapeutic use Treatment Outcome Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:	BACKGROUND AND PURPOSE—Interventional Management of Stroke (IMS) III is a randomized, parallel arm trial comparing the approach of intravenous tissue-type plasminogen activator followed by endovascular treatment with intravenous tissue-type plasminogen activator alone in patients with acute ischemic stroke presenting
ISSN:	0039-2499 1524-4628
DOI:	10.1161/STROKEAHA.113.003925