LDL Cholesterol and the Development of Stroke Subtypes and Coronary Heart Disease in a General Japanese Population: The Hisayama Study

LDL Cholesterol and the Development of Stroke Subtypes and Coronary Heart Disease in a General Japanese Population: The Hisayama Study

BACKGROUND AND PURPOSE—Although the relation between serum LDL cholesterol level and coronary heart disease (CHD) is well established, its relation with stroke subtypes is less clear. METHODS—A total of 2351 inhabitants age ≥40 years in a Japanese community were followed up for 19 years. RESULTS—Dur...

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Veröffentlicht in:Stroke (1970) 2009-02, Vol.40 (2), p.382-388
Hauptverfasser: Imamura, Tsuyoshi, Doi, Yasufumi, Arima, Hisatomi, Yonemoto, Koji, Hata, Jun, Kubo, Michiaki, Tanizaki, Yumihiro, Ibayashi, Setsuro, Iida, Mitsuo, Kiyohara, Yutaka
Format: Artikel
Sprache:eng
Schlagworte:
Age Factors
Aged
Analysis of Variance
Biological and medical sciences
Cardiovascular Diseases - epidemiology
Cholesterol, LDL - blood
Cohort Studies
Coronary Disease - blood
Coronary Disease - epidemiology
Female
Follow-Up Studies
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Health Surveys
Humans
Japan - epidemiology
Male
Medical sciences
Middle Aged
Myocardial Infarction - epidemiology
Nervous system (semeiology, syndromes)
Neurology
Prospective Studies
Risk Factors
Sex Factors
Stroke - blood
Stroke - classification
Stroke - epidemiology
Terminology as Topic
Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:BACKGROUND AND PURPOSE—Although the relation between serum LDL cholesterol level and coronary heart disease (CHD) is well established, its relation with stroke subtypes is less clear. METHODS—A total of 2351 inhabitants age ≥40 years in a Japanese community were followed up for 19 years. RESULTS—During follow-up, 271 subjects developed stroke and 144 developed CHD. Whereas the age- and sex-adjusted incidences of CHD significantly increased with increasing LDL cholesterol levels (P for trend
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.108.529537