Body Composition in Young Adults Living With a Fontan Circulation: The Myopenic Profile

Body Composition in Young Adults Living With a Fontan Circulation: The Myopenic Profile

Background We sought to characterize body composition abnormalities in young patients living with a Fontan circulation and explore potential pathophysiologic associations. Methods and Results Twenty-eight patients with a Fontan circulation were prospectively recruited in this cross-sectional study....

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Veröffentlicht in:Journal of the American Heart Association 2020-04, Vol.9 (8), p.e015639
Hauptverfasser: Tran, Derek, D'Ambrosio, Paolo, Verrall, Charlotte E, Attard, Chantal, Briody, Julie, D'Souza, Mario, Fiatarone Singh, Maria, Ayer, Julian, d'Udekem, Yves, Twigg, Stephen, Davis, Glen M, Celermajer, David S, Cordina, Rachael
Format: Artikel
Sprache:eng
Schlagworte:
Adiposity
Adult
Age Factors
Body Composition
Body Mass Index
congenital heart disease
Cross-Sectional Studies
exercise capacity
Exercise Tolerance
Female
Fontan Procedure - adverse effects
Functional Status
Heart Defects, Congenital - surgery
Humans
Male
Muscle Strength
muscle wasting
Muscle, Skeletal - diagnostic imaging
Muscle, Skeletal - physiopathology
Muscular Atrophy - diagnostic imaging
Muscular Atrophy - etiology
Muscular Atrophy - physiopathology
obesity
Original Research
Prospective Studies
single ventricle
Time Factors
Treatment Outcome
Young Adult
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Zusammenfassung:Background We sought to characterize body composition abnormalities in young patients living with a Fontan circulation and explore potential pathophysiologic associations. Methods and Results Twenty-eight patients with a Fontan circulation were prospectively recruited in this cross-sectional study. Participants underwent cardiopulmonary exercise testing, dual-energy X-ray absorptiometry, echocardiography, and biochemical assessment. Mean age was 26±7 years. Skeletal muscle mass, estimated by appendicular lean mass index Z score, was reduced compared with reference data (-1.49±1.10,
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.119.015639