Angiotensin (1-7) Receptor Antagonism Equalizes Angiotensin II-Induced Hypertension in Male and Female Spontaneously Hypertensive Rats

Females are less sensitive to the hypertensive effects of angiotensin II compared with males, although the molecular mechanisms responsible are unknown. We hypothesize that differential activation of angiotensin II, angiotensin (1-7), angiotensin II type 1, angiotensin II type 2, and mas levels in t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2010-10, Vol.56 (4), p.658-666
Hauptverfasser:	Sullivan, Jennifer C, Bhatia, Kanchan, Yamamoto, Tatsuo, Elmarakby, Ahmed A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin I - metabolism Angiotensin II - analogs & derivatives Angiotensin II - blood Angiotensin II - metabolism Angiotensin II - pharmacology Angiotensin II - toxicity Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Blotting, Western Cardiology. Vascular system Experimental diseases Female Hypertension - chemically induced Hypertension - physiopathology Kidney Cortex - drug effects Kidney Cortex - metabolism Male Medical sciences Peptide Fragments - metabolism Peptide Fragments - pharmacology Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Rats Rats, Inbred SHR Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism Receptor, Angiotensin, Type 2 - genetics Receptor, Angiotensin, Type 2 - metabolism Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Reverse Transcriptase Polymerase Chain Reaction Sex Factors Vasoconstrictor Agents - blood Vasoconstrictor Agents - metabolism Vasoconstrictor Agents - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Females are less sensitive to the hypertensive effects of angiotensin II compared with males, although the molecular mechanisms responsible are unknown. We hypothesize that differential activation of angiotensin II, angiotensin (1-7), angiotensin II type 1, angiotensin II type 2, and mas levels in the renal cortex of male and female spontaneously hypertensive rats contribute to sex differences in the blood pressure response to angiotensin II infusion. Males had a greater increase in blood pressure after angiotensin II infusion than females (males150±2 to 186±3 mm Hg; females137±3 to 160±4 mm Hg; P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/HYPERTENSIONAHA.110.153668