Heparin Impairs Glycocalyx Barrier Properties and Attenuates Shear Dependent Vasodilation in Mice

The endothelial glycocalyx is a hydrated mesh of polysaccharides and adsorbed plasma proteins that forms the true interface between the flowing blood and the endothelium. We hypothesized in the present study that competitive binding of heparin to glycocalyx-associated proteins would affect glycocaly...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2007-07, Vol.50 (1), p.261-267
Hauptverfasser:	VanTeeffelen, Jurgen W.G.E, Brands, Judith, Jansen, Carin, Spaan, Jos A.E, Vink, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants - pharmacology Arterial hypertension. Arterial hypotension Arterioles - physiopathology Biological and medical sciences Biological Availability Blood and lymphatic vessels Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Dextrans - blood Endothelium, Vascular - physiology Fundamental and applied biological sciences. Psychology Glycocalyx - drug effects Glycocalyx - metabolism Hemodynamics. Rheology Heparin - pharmacology Hyaluronoglucosaminidase - pharmacology Hyperemia - chemically induced Hyperemia - physiopathology Mechanotransduction, Cellular - physiology Medical sciences Mice Mice, Inbred C57BL Muscle, Skeletal - blood supply Nitric Oxide - metabolism Stress, Mechanical Vasodilation - drug effects Vertebrates: cardiovascular system
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Zusammenfassung:	The endothelial glycocalyx is a hydrated mesh of polysaccharides and adsorbed plasma proteins that forms the true interface between the flowing blood and the endothelium. We hypothesized in the present study that competitive binding of heparin to glycocalyx-associated proteins would affect glycocalyx barrier properties and mechanotransduction of shear stress to the endothelium. In anesthetized mice, the clearance of 70-kDa dextrans from the circulation was increased (P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/HYPERTENSIONAHA.107.089250