Organ-Specific Protection Against Lipopolysaccharide-Induced Vascular Leak Is Dependent on the Endothelial Protein C Receptor

OBJECTIVE—To study the role of the endothelial protein C receptor (EPCR) in the modulation of susceptibility to inflammation-induced vascular leak in vivo. APPROACH AND RESULTS—Genetically modified mice with low,

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Bibliographische Detailangaben
Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2013-04, Vol.33 (4), p.769-776
Hauptverfasser:	von Drygalski, Annette, Furlan-Freguia, Christian, Ruf, Wolfram, Griffin, John H, Mosnier, Laurent O
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - chemically induced Albuminuria - metabolism Animals Brain - blood supply Brain - pathology Capillary Permeability Disease Models, Animal Endothelial Protein C Receptor Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endotoxemia - chemically induced Endotoxemia - metabolism Endotoxemia - pathology Evans Blue - metabolism Female Glycoproteins - deficiency Glycoproteins - genetics Glycoproteins - metabolism Hemorrhage - chemically induced Hemorrhage - metabolism Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology Kidney - blood supply Kidney - pathology Lipopolysaccharides Lung - blood supply Lung - pathology Lung Injury - chemically induced Lung Injury - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Plasma Volume Protein Binding Receptors, Cell Surface Serum Albumin - metabolism Time Factors
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Zusammenfassung:	OBJECTIVE—To study the role of the endothelial protein C receptor (EPCR) in the modulation of susceptibility to inflammation-induced vascular leak in vivo. APPROACH AND RESULTS—Genetically modified mice with low,
ISSN:	1079-5642 1524-4636
DOI:	10.1161/ATVBAHA.112.301082