CCL20 Is Increased in Hypercholesterolemic Subjects and Is Upregulated By LDL in Vascular Smooth Muscle Cells: Role of NF-κB

OBJECTIVE—Our aim was to analyze the regulation of CC Chemokine ligand 20 (CCL20) by LDL in human vascular smooth muscle cells (VSMC). METHODS AND RESULTS—In asymptomatic subjects, circulating CCL20 levels were higher in patients with hypercholesterolemia (18.5±3.2 versus 9.1±1.3 pg/mL; P

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-11, Vol.31 (11), p.2733-2741
Hauptverfasser:	Calvayrac, Olivier, Rodríguez-Calvo, Ricardo, Alonso, Judith, Orbe, Josune, Martín-Ventura, Jose Luis, Guadall, Anna, Gentile, Maurizio, Juan-Babot, Oriol, Egido, Jesus, Beloqui, Oscar, Paramo, José A, Rodríguez, Cristina, Martínez-González, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aorta - metabolism Aorta - pathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Cells, Cultured Chemokine CCL20 - metabolism Coronary Artery Disease - metabolism Coronary Artery Disease - pathology Coronary Artery Disease - surgery Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Dose-Response Relationship, Drug Endarterectomy Female Fundamental and applied biological sciences. Psychology Humans Hypercholesterolemia - metabolism Lipoproteins, LDL - pharmacology Male Medical sciences Middle Aged Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology NF-kappa B - metabolism Signal Transduction Time Factors Up-Regulation - drug effects Up-Regulation - physiology Vertebrates: cardiovascular system
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Zusammenfassung:	OBJECTIVE—Our aim was to analyze the regulation of CC Chemokine ligand 20 (CCL20) by LDL in human vascular smooth muscle cells (VSMC). METHODS AND RESULTS—In asymptomatic subjects, circulating CCL20 levels were higher in patients with hypercholesterolemia (18.5±3.2 versus 9.1±1.3 pg/mL; P
ISSN:	1079-5642 1524-4636
DOI:	10.1161/ATVBAHA.111.235721