Platelets from flowing blood attach to the inflammatory chemokine CXCL16 expressed in the endothelium of the human vessel wall

Summary Endothelial chemokine CXC motif ligand 16 (CXCL16) expression is associated with atherosclerosis, while platelets, particularly those attaching to atherosclerotic plaque, contribute to all stages of athero-sclerotic disease. This investigation was designed to examine the role of CXCL16 in ca...

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Veröffentlicht in:	Thrombosis and haemostasis 2015-08, Vol.113 (2), p.297-312
Hauptverfasser:	Santos, Sascha Meyer dos, Blankenbach, Kira, Scholich, Klaus, Dörr, Angela, Monsefi, Nadejda, Keese, Michael, Linke, Bona, Deckmyn, Hans, Nelson, Karen, Harder, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Blood Platelets - metabolism Blood Platelets - pathology Calcium - blood Calcium Signaling Carotid Artery Diseases - metabolism Carotid Artery Diseases - pathology Carotid Artery Diseases - surgery Cellular Haemostasis and Platelets Chemokine CXCL16 Chemokines, CXC - metabolism Endarterectomy, Carotid Endothelium, Vascular - metabolism Hemorheology Human Umbilical Vein Endothelial Cells Humans Immobilized Proteins - metabolism Immunoglobulin Fab Fragments - pharmacology In Vitro Techniques Ligands Plaque, Atherosclerotic - blood Plaque, Atherosclerotic - pathology Platelet Adhesiveness Platelet Aggregation Platelet Glycoprotein GPIb-IX Complex - antagonists & inhibitors Receptors, Chemokine - antagonists & inhibitors Receptors, Chemokine - physiology Receptors, CXCR6 Receptors, Scavenger - metabolism Receptors, Virus - antagonists & inhibitors Receptors, Virus - physiology von Willebrand Factor - metabolism
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