Thrombocytopenia after abciximab use results from different mechanisms

Summary Our study concerns thrombocytopenia in patients with acute ischaemic coronary artery disease receiving antiplatelet drugs to the αIIbβ3 inte-grin (GPIIb/IIIa). We have screened for drug-dependent antibodies (DDAB) in 18 patients who suffered a fall of > 50% in platelet count (9 patients h...

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Veröffentlicht in:	Thrombosis and haemostasis 2010-03, Vol.103 (3), p.651-661
Hauptverfasser:	Lajus, Sophie, Clofent-Sanchez, Gisèle, Jais, Catherine, Coste, Pierre, Nurden, Paquita, Nurden, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - immunology Autoantibodies - blood Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - immunology Cardiology. Vascular system Coronary Artery Disease Coronary heart disease Female Fundamental and applied biological sciences. Psychology Heart Hematologic and hematopoietic diseases Humans Immunoglobulin Fab Fragments - adverse effects Immunoglobulin Fab Fragments - immunology Male Medical sciences Middle Aged Molecular and cellular biology Platelet Activation - immunology Platelet Count Platelet diseases and coagulopathies Platelet Glycoprotein GPIIb-IIIa Complex - immunology Platelets and Blood Cells Thrombocytopenia - complications Thrombocytopenia - drug therapy
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Zusammenfassung:	Summary Our study concerns thrombocytopenia in patients with acute ischaemic coronary artery disease receiving antiplatelet drugs to the αIIbβ3 inte-grin (GPIIb/IIIa). We have screened for drug-dependent antibodies (DDAB) in 18 patients who suffered a fall of > 50% in platelet count (9 patients had a nadir of
ISSN:	0340-6245 2567-689X
DOI:	10.1160/TH09-08-0603