Exclusion of the α2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample

Exclusion of the α2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample

Summary Protein C deficiency increases the risk of venous thromboembolic disease among members of KindredVermont II, but fails to fully account for the inheritance pattern. A genome scan of the pedigree supported the presence of a prothrombotic gene on chromosome 11q23 (107–119Mb, nominal P

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Veröffentlicht in:Thrombosis and haemostasis 2007, Vol.97 (9), p.587-592
Hauptverfasser: Hasstedt, Sandra J., Scott, Bruce T., Rosendaal, Frits R., Callas, Peter W., Vossen, Carla Y., Long, George L., Bovill, Edwin G.
Format: Artikel
Sprache:eng
Schlagworte:
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
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Zusammenfassung:Summary Protein C deficiency increases the risk of venous thromboembolic disease among members of KindredVermont II, but fails to fully account for the inheritance pattern. A genome scan of the pedigree supported the presence of a prothrombotic gene on chromosome 11q23 (107–119Mb, nominal P
ISSN:0340-6245
2567-689X
DOI:10.1160/TH07-02-0134