Sustained Complete Remission in Multi-Relapsed Primary CNS Lymphoma Treated with Ibrutinib Monotherapy: A Case Report

Sustained Complete Remission in Multi-Relapsed Primary CNS Lymphoma Treated with Ibrutinib Monotherapy: A Case Report

Abstract Primary CNS lymphoma (PCNSL) is a highly aggressive malignant disease with a high recurrence rate and a poor prognosis. We present the case of a 71-year-old woman diagnosed with PCNSL in June 2010. After 3 relapses and intensive treatment with multiple chemotherapy regimens and whole-brain...

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Veröffentlicht in:Case Reports in Oncology 2021-09, Vol.14 (3), p.1337-1341
Hauptverfasser: Mair, Anna, Muigg, Armin, Stockhammer, Günther, Mangesius, Stephanie, Wolf, Dominik, Gunsilius, Eberhard
Format: Artikel
Sprache:eng
Schlagworte:
Biopsy
Blood-brain barrier
Cancer
Cancer regression
Cancer therapies
Care and treatment
Case Report
Case reports
Chemotherapy
Diagnosis
Drug dosages
Health aspects
ibrutinib
Immunoglobulins
Inhibitor drugs
Lymphoma
Medical prognosis
Mutation
Nervous system
Non-Hodgkin's lymphomas
Observations
Patient outcomes
Patients
primary cns lymphoma
Radiation therapy
Remission (Medicine)
Risk factors
Stem cell transplantation
Targeted cancer therapy
Tomography
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Zusammenfassung:Abstract Primary CNS lymphoma (PCNSL) is a highly aggressive malignant disease with a high recurrence rate and a poor prognosis. We present the case of a 71-year-old woman diagnosed with PCNSL in June 2010. After 3 relapses and intensive treatment with multiple chemotherapy regimens and whole-brain radiotherapy, she received off-label treatment with the Bruton tyrosine kinase inhibitor ibrutinib, responded well, achieved a complete remission, and is progression-free for now >3 years.
ISSN:1662-6575
1662-6575
DOI:10.1159/000518528