Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report
The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenoc...
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| Veröffentlicht in: | Case reports in oncology 2018-02, Vol.11 (1), p.109-113 |
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| container_title | Case reports in oncology |
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| creator | Mitsogianni, Maria Mitsimponas, Nikolaos Crespo, Felipe Hartmann, Karl Axel Klosterhalfen, Bernd Haase, Sabine Giagounidis, Aristoteles |
| description | The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenocarcinoma suffering from concomitant hairy cell leukemia. The identification of an identical BRAF mutation in both malignancies raises physiopathological considerations and might offer unique therapeutic strategies for this group of patients. |
| doi_str_mv | 10.1159/000486640 |
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| subjects | Anemia Bone marrow BRAF-V600E mutation Cancer therapies Case Report Case reports Cell cycle Colorectal cancer Disease Driver mutations Esophagus Hairy cell leukemia Immunotherapy Kinases Leukemia Lung adenocarcinoma Lung cancer Melanoma Mutation Neutrophils Non-small cell lung cancer Skin cancer Tumors |
| title | Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report |
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