Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report

Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report

The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenoc...

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Veröffentlicht in:Case reports in oncology 2018-02, Vol.11 (1), p.109-113
Hauptverfasser: Mitsogianni, Maria, Mitsimponas, Nikolaos, Crespo, Felipe, Hartmann, Karl Axel, Klosterhalfen, Bernd, Haase, Sabine, Giagounidis, Aristoteles
Format: Artikel
Sprache:eng
Schlagworte:
Anemia
Bone marrow
BRAF-V600E mutation
Cancer therapies
Case Report
Case reports
Cell cycle
Colorectal cancer
Disease
Driver mutations
Esophagus
Hairy cell leukemia
Immunotherapy
Kinases
Leukemia
Lung adenocarcinoma
Lung cancer
Melanoma
Mutation
Neutrophils
Non-small cell lung cancer
Skin cancer
Tumors
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Zusammenfassung:The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenocarcinoma suffering from concomitant hairy cell leukemia. The identification of an identical BRAF mutation in both malignancies raises physiopathological considerations and might offer unique therapeutic strategies for this group of patients.
ISSN:1662-6575
1662-6575
DOI:10.1159/000486640