Metabolomics of Chronic Kidney Disease Progression: A Case-Control Analysis in the Chronic Renal Insufficiency Cohort Study

Metabolomics of Chronic Kidney Disease Progression: A Case-Control Analysis in the Chronic Renal Insufficiency Cohort Study

Background: Whereas several longitudinal metabolomics studies have been conducted in individuals with normal estimated glomerular filtration rate (eGFR) at baseline, disease progression among individuals with established chronic kidney disease (CKD) has not been rigorously examined. Methods: We perf...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of nephrology 2016-01, Vol.43 (5), p.366-374
Hauptverfasser: Rhee, Eugene P., Clish, Clary B., Wenger, Julia, Roy, Jason, Elmariah, Sammy, Pierce, Kerry A., Bullock, Kevin, Anderson, Amanda H., Gerszten, Robert E., Feldman, Harold I.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Biological markers
Case-Control Studies
Chronic kidney failure
Cohort Studies
Development and progression
Diagnosis
Disease Progression
Female
Health aspects
Humans
Identification and classification
Male
Metabolites
Metabolome
Metabolomics
Middle Aged
Original Report: Patient-Oriented, Translational Research
Renal Insufficiency, Chronic - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background: Whereas several longitudinal metabolomics studies have been conducted in individuals with normal estimated glomerular filtration rate (eGFR) at baseline, disease progression among individuals with established chronic kidney disease (CKD) has not been rigorously examined. Methods: We performed a nested case-control study of rapid CKD progression in the Chronic Renal Insufficiency Cohort Study, profiling baseline plasma from 200 individuals each with eGFR slope
ISSN:0250-8095
1421-9670
DOI:10.1159/000446484