Interlukin-10, Interferon-γ and Tumor Necrosis Factor-α Genes Variation in Prostate Cancer and Benign Prostatic Hyperplasia

Background: The genetic background of prostate cancer (PCa) is not completely understood. Objective: To assess whether an association exists between interlukin-10 (IL-10), interferon-γ(IFN-γ), tumor necrosis factor-α(TNF-α) poly-morphisms and PCa and benign prostatic hyperplasia (BPH). Patients and Methods: Forty-one patients with PCa, 100 pa-tients with BPH and 100 healthy individuals were genotyped using the allele-specific oligonucleotide-polymerase chain reaction method. Results: The moderate expressing form of IFN-γ+874 (A/T) polymorphism is more frequent in PCa and BPH cases. The homozygous form of G/G or A/A genotype of IL-10 –1082 cytokine was significantly increased in the pa-tients groups. The TNF-α–308 polymorphism significant in-creased in low producing G/G genotyped in the PCa group. Conclusion: IL-10, IFN-γ, TNF-αexpression levels may play a role in the development of PCa and BPH.