Oxidized Low-Density Lipoprotein and Oxidative Stress in the Development of Glomerulosclerosis
Glomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the p...
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| Veröffentlicht in: | American journal of nephrology 2009-01, Vol.29 (1), p.62-70 |
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| container_title | American journal of nephrology |
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| creator | Lee, Hyun Soon Song, Chi Young |
| description | Glomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed. |
| doi_str_mv | 10.1159/000151277 |
| format | Article |
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Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed.</description><identifier>ISSN: 0250-8095</identifier><identifier>EISSN: 1421-9670</identifier><identifier>DOI: 10.1159/000151277</identifier><identifier>PMID: 18689980</identifier><identifier>CODEN: AJNED9</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Antioxidants - metabolism ; Enzyme Activation ; Glomerulonephritis - metabolism ; Glomerulonephritis - pathology ; Humans ; In-Depth Topic Review ; Lipid Peroxidation ; Lipoproteins, LDL - metabolism ; MAP Kinase Signaling System ; Mesangial Cells - metabolism ; Mesangial Cells - pathology ; NADPH Oxidases - metabolism ; Oxidative Stress ; Oxygen - metabolism ; Protein Kinase C - antagonists & inhibitors ; Renin-Angiotensin System ; Signal Transduction ; Transforming Growth Factor beta - metabolism</subject><ispartof>American journal of nephrology, 2009-01, Vol.29 (1), p.62-70</ispartof><rights>2008 S. Karger AG, Basel</rights><rights>Copyright 2008 S. Karger AG, Basel.</rights><rights>Copyright (c) 2008 S. 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Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed.</description><subject>Antioxidants - metabolism</subject><subject>Enzyme Activation</subject><subject>Glomerulonephritis - metabolism</subject><subject>Glomerulonephritis - pathology</subject><subject>Humans</subject><subject>In-Depth Topic Review</subject><subject>Lipid Peroxidation</subject><subject>Lipoproteins, LDL - metabolism</subject><subject>MAP Kinase Signaling System</subject><subject>Mesangial Cells - metabolism</subject><subject>Mesangial Cells - pathology</subject><subject>NADPH Oxidases - metabolism</subject><subject>Oxidative Stress</subject><subject>Oxygen - metabolism</subject><subject>Protein Kinase C - antagonists & inhibitors</subject><subject>Renin-Angiotensin System</subject><subject>Signal Transduction</subject><subject>Transforming Growth Factor beta - metabolism</subject><issn>0250-8095</issn><issn>1421-9670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0E1LxDAQBuAgiq6rB-8iwYPgoTppmjQ5yq5fsOBBz5ZsO9Vo26xJ69evN8suCp4C4Zlh3peQAwZnjAl9DgBMsDTPN8iIZSlLtMxhk4wgFZAo0GKH7IbwElWqIN8mO0xJpbWCEXm8-7SV_caKztxHMsUu2P6LzuzCLbzr0XbUdBVdItPbd6T3vccQaPzvn5FO8R0bt2ix66mr6XXjWvRD40LZoHfBhj2yVZsm4P76HZOHq8uHyU0yu7u-nVzMkpLrvE808AzjTUbJjGcxUsa5FIKLuja15iI1YEpVzktTgQQ-r6o4YYRkag51XvExOVmtjUe_DRj6orWhxKYxHbohFFLmaQyvIzz-B1_c4Lt4WpFyqTMFYolOV6iMGYLHulh42xr_VTAoloUXv4VHe7ReOMxbrP7kuuEIDlfg1fgn9H9gNf8DdAODnQ</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Lee, Hyun Soon</creator><creator>Song, Chi Young</creator><general>S. 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| identifier | ISSN: 0250-8095 |
| ispartof | American journal of nephrology, 2009-01, Vol.29 (1), p.62-70 |
| issn | 0250-8095 1421-9670 |
| language | eng |
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| source | Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Antioxidants - metabolism Enzyme Activation Glomerulonephritis - metabolism Glomerulonephritis - pathology Humans In-Depth Topic Review Lipid Peroxidation Lipoproteins, LDL - metabolism MAP Kinase Signaling System Mesangial Cells - metabolism Mesangial Cells - pathology NADPH Oxidases - metabolism Oxidative Stress Oxygen - metabolism Protein Kinase C - antagonists & inhibitors Renin-Angiotensin System Signal Transduction Transforming Growth Factor beta - metabolism |
| title | Oxidized Low-Density Lipoprotein and Oxidative Stress in the Development of Glomerulosclerosis |
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