Oxidized Low-Density Lipoprotein and Oxidative Stress in the Development of Glomerulosclerosis

Glomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the p...

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Veröffentlicht in:	American journal of nephrology 2009-01, Vol.29 (1), p.62-70
Hauptverfasser:	Lee, Hyun Soon, Song, Chi Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - metabolism Enzyme Activation Glomerulonephritis - metabolism Glomerulonephritis - pathology Humans In-Depth Topic Review Lipid Peroxidation Lipoproteins, LDL - metabolism MAP Kinase Signaling System Mesangial Cells - metabolism Mesangial Cells - pathology NADPH Oxidases - metabolism Oxidative Stress Oxygen - metabolism Protein Kinase C - antagonists & inhibitors Renin-Angiotensin System Signal Transduction Transforming Growth Factor beta - metabolism
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Beschreibung
Zusammenfassung:	Glomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed.
ISSN:	0250-8095 1421-9670
DOI:	10.1159/000151277