Monoclonal Antibodies to Polioviruses

Monoclonal Antibodies to Polioviruses

Murine lymphocyte hybridomas which produce neutralizing or non-neutralizing monoclonal antibodies to different type 1, 2 or 3 poliovirus strains were isolated. The majority of these monoclonal antibodies reacted with antigenic determinants present on different polio-virus strains of the same type. H...

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Veröffentlicht in:Intervirology 2008-07, Vol.16 (4), p.218-224
Hauptverfasser: Osterhaus, Albert D.M.E., van Wezel, Anton L., van Steenis, Bert, Drost, Gerben A., Hazendonk, Ton G.
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Sprache:eng
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Zusammenfassung:Murine lymphocyte hybridomas which produce neutralizing or non-neutralizing monoclonal antibodies to different type 1, 2 or 3 poliovirus strains were isolated. The majority of these monoclonal antibodies reacted with antigenic determinants present on different polio-virus strains of the same type. However, hybridomas producing monoclonal antibodies specific for each of the three Sabin vaccine strains were also generated.
ISSN:0300-5526
1423-0100
DOI:10.1159/000149270