Neuropsychiatric Syndromes in Dementia

Background/Aims: The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer’s disease (AD). Methods: Cross-sectional data of 2,354 patients with AD from 12 centres from the European Alzheimer’s Disease Consort...

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Veröffentlicht in:Dementia and geriatric cognitive disorders 2007, Vol.24 (6), p.457-463
Hauptverfasser: Aalten, Pauline, Verhey, Frans R.J., Boziki, Marina, Bullock, Roger, Byrne, Eleanor Jane, Camus, Vincent, Caputo, Miriam, Collins, Debby, De Deyn, Peter Paul, Elina, Kazi, Frisoni, Giovanni, Girtler, Nicola, Holmes, Clive, Hurt, Catherine, Marriott, Anna, Mecocci, Patrizia, Nobili, Flavio, Ousset, Pierre Jean, Reynish, Emma, Salmon, Eric, Tsolaki, Magda, Vellas, Bruno, Robert, Philippe H.
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Sprache:eng
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Zusammenfassung:Background/Aims: The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer’s disease (AD). Methods: Cross-sectional data of 2,354 patients with AD from 12 centres from the European Alzheimer’s Disease Consortium were collected. Principal component analysis was used for factor analysis. Results: The results showed the presence of 4 neuropsychiatric subsyndromes: hyperactivity, psychosis, affective symptoms and apathy. The subsyndrome apathy was the most common, occurring in almost 65% of the patients. Conclusion: This large study has provided additional robust evidence for the existence of neuropsychiatric subsyndromes in AD.
ISSN:1420-8008
1421-9824
DOI:10.1159/000110738