Fine Mapping of the Schizophrenia Susceptibility Locus on Chromosome 1q22

Schizophrenia is a serious neuropsychiatric illness estimated to affect approximately 1% of the general population. As part of a genome scan for schizophrenia susceptibility loci, we have previously reported a maximum heterogeneity four-point lod score of 6.50 on chromosome 1q21-22 in a group of 22...

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Veröffentlicht in:	Human heredity 2002-01, Vol.54 (4), p.199-209
Hauptverfasser:	Brzustowicz, Linda M., Hayter, Jared E., Hodgkinson, Kathleen A., Chow, Eva W.C., Bassett, Anne S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD Base Sequence Chromosome Mapping - methods Chromosomes, Human, Pair 1 DNA Primers Exons Gene Duplication Genetic Linkage Genetic Markers Genetic Predisposition to Disease - genetics GPI-Linked Proteins Heterozygote Homozygote Humans Isoantigens - genetics Lod Score Original Paper Receptors, IgG - genetics Schizophrenia - genetics Sensitivity and Specificity
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Zusammenfassung:	Schizophrenia is a serious neuropsychiatric illness estimated to affect approximately 1% of the general population. As part of a genome scan for schizophrenia susceptibility loci, we have previously reported a maximum heterogeneity four-point lod score of 6.50 on chromosome 1q21-22 in a group of 22 medium-sized Canadian families, selected for study because multiple relatives were clinically diagnosed with schizophrenia or schizoaffective disorder. We have now conducted fine mapping of this locus in the same set of individuals using 15 genetic markers spanning an ~ 15-cM interval. Parametric linkage analysis with GENEHUNTER v2.1 and VITESSE v2.0 produced a maximum multipoint heterogeneity lod score of 6.50, with a Zmax-1 support interval of
ISSN:	0001-5652 1423-0062
DOI:	10.1159/000070665