Variation in Pilosebaceous Duct Keratinocyte Proliferation in Acne Patients

Sorry, there is no abstract available. Read the first few lines of the text instead! The precise pathological processes of comedo formation are not well understood. In patients with acne, there are changes in the process of cornification within the sebaceous follicle. It is thought that an increase in proliferating keratinocytes [1, 2] and their subsequent retention are factors which contribute to this process. In order to investigate the early events involved in the initiation of comedogenesis, normal follicles from acne patients have been labelled using immunohistochemistry with antibodies to Ki-67 and keratin 16 (K16). Ki-67 is a non-histone protein which labels all cycling cells except those in G0, whereas K16 is a protein which is up-regulated in all abnormally differentiating and hyperproliferating suprabasal keratinocytes.